郵箱: weijunpan@sinh.ac.cn
電話(huà): +86-21-54923309
所屬部門(mén): 中國(guó)科學(xué)院營(yíng)養(yǎng)代謝與食品安全重點(diǎn)實(shí)驗(yàn)室
2017-至 今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2012-2016年：中國(guó)科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所 研究員
2009-2012年：美國(guó)國(guó)立衛(wèi)生研究院 兒童健康與人類(lèi)發(fā)育研究所 博士后
2005-2009年：美國(guó)耶魯大學(xué)，醫(yī)學(xué)院藥學(xué)系 博士后
1999-2005年：中國(guó)科學(xué)院上海生命科學(xué)研究院生化與細(xì)胞所 理學(xué)博士 導(dǎo)師：李林 研究員
1995-1999年：華東理工大學(xué) 生物工程學(xué)院 生物化學(xué)系 理學(xué)學(xué)士
造血-循環(huán)系統(tǒng)的發(fā)育與穩(wěn)態(tài)
主要從事造血-循環(huán)系統(tǒng)發(fā)育與穩(wěn)態(tài)調(diào)控的信號(hào)轉(zhuǎn)導(dǎo)機(jī)理研究。通過(guò)整合遺傳篩選、遺傳定位和活體成像、單細(xì)胞分析、生化分析和小分子化合物大規(guī)模篩選等研究手段，探索微環(huán)境信號(hào)網(wǎng)絡(luò)調(diào)控中胚層組織器官共發(fā)育、穩(wěn)態(tài)維持及相關(guān)疾病過(guò)程的分子機(jī)制。近期重點(diǎn)研究：（1）血管與造血干細(xì)胞協(xié)同發(fā)育；（2）血管網(wǎng)絡(luò)形成及穩(wěn)態(tài)調(diào)控；（3）造血干細(xì)胞歸巢及增殖分化的分子細(xì)胞調(diào)控基礎(chǔ)，聚焦若干跨膜蛋白質(zhì)分子、酯/脂質(zhì)分子及膜動(dòng)態(tài)平衡為核心的信號(hào)轉(zhuǎn)導(dǎo)機(jī)制研究，積極推進(jìn)相關(guān)人類(lèi)疾病致病機(jī)理及臨床轉(zhuǎn)化應(yīng)用研究。
1.?Shuang Wu#, Kai Chen#, Tao Xu#, Ke Ma, Lei Gao, Cong Fu, Wenjuan Zhang, Changbin Jing, Chunguang Ren, Min Deng, Yi Chen, Yi Zhou, Weijun Pan*, Xiaoe Jia*. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Front Cell Dev Biol 2021 Oct 13;9:709923.
2.?Xiaofen Liu, Wenjuan Zhang, Changbin Jing, Lei Gao, Cong Fu, Chunguang Ren, Yimei Hao, Mengye Cao, Ke Ma*, Weijun Pan*, Dantong Li*. Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis. Front Cell Dev Biol 2021 Apr 30;9:670654.
3.?Lantian Wang#, Jing Fan#, Lili Han#, Haonan Qi#, Yimin Wang, Hongye Wang, Suli Chen, Lei Du, Sheng Li, Yunbin Zhang, Wei Tang, Gaoxiang Ge, Weijun Pan*, Ping Hu*, Hong Cheng*. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis 2020 May 11;11(5):357.
4.?Wencao Zhao#, Le Cao#, Hanru Ying#, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Mengye Cao, Cong Fu, Haonan Qi, Yimei Hao, Yun-Chi Tang, Jun Qin, Tao P Zhong, Xiaoxi Lin, Luyang Yu, Xuri Li, Lin Li, Dianqing Wu, Weijun Pan*. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res 2019 Nov;29(11):895-910.
5.?Dantong Li#, Wenzhi Xue#, Mei Li#, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O. Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu，Weijun Pan*. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature 2018 Dec;564(7734):119-124.
6.?Xiaoli He#, Wenjuan Zhang#, Chen Yan#, Fen Nie, Chen Li, Xiaofen Liu, Cong Fei, Shengdi Li, Xiaomin Song, Yingying Jia, Rong Zeng, Dianqing Wu, Weijun Pan*, Xiaojiang Hao*, Lin Li*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov 2017 Jan 31;3:1700.
7.?Xiao-E Jia#, Tao Xu#, Ke Ma#, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I. Zon, Yi Zhou*, Saijuan Chen*, Weijun Pan*. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res 2015 Aug;25(8):946-962.
8.?Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiaoe Jia, Shuang Wu, XinSun, Mei Dong, Min Deng, Yi Chen, Wenge Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon, Weijun Pan*. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet 2015 Jul 1;11(7):e1005346.
9.?Ingyu Kim#, Weijun Pan#*, Sara A. Jones, Youxin Zhang, Xiaowei Zhuang, Dianqing Wu*. Clathrin and AP2 are required for PtdIns(4,5)P-2-mediated formation of LRP6 signalosomes. J Cell Biol 2013 Feb 18;200(4):419-428.
10.?Weijun Pan#, Van N. Pham#, Amber N. Stratman, Daniel Castranova, Makoto Kamei, Kameha R. Kidd, Brigid D. Lo, Kenna M. Shaw, Jesus Torres-Vazquez, Constantinos M. Mikelis, Silvio J. Gutkind, George E. Davis, Brant M. Weinstein. CDP-diacylglycerolsynthetase-controlled phosphoinositide availability limitsVEGFA signaling and vascular morphogenesis. Blood 2012 Jul 12;120(2):489-498.
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