郵箱: ycqian@sinh.ac.cn
電話: +86-21-54923331
所屬部門: 中國科學院腫瘤與微環境重點實驗室
2017-至 今：中國科學院上海營養與健康研究所，研究員
2007-2016年：中國科學院上海生命科學研究院/上海交通大學醫學院健康科學研究所，研究員
2005-2007年：美國克利夫蘭臨床基金會，課題研究員(project staff，相當于高校研究助理教授)
2003-2005年：美國克利夫蘭臨床基金會，研究助理(Research Associate)
2000-2003年：美國克利夫蘭臨床基金會，博士后
1996-1999年：中國科學院上海藥物研究所，藥理學(分子生物學)專業博士生
1990-1996年：揚州制藥研究所，生物藥品開發工程師
1987-1990年：南京師范大學生物系，細胞生物學專業碩士生
1983-1987年：南京師范大學生物系，本科生
炎癥相關重大疾病
通過小鼠動物模型結合臨床病人樣本研究炎癥相關重大疾病（自身免疫病、感染性疾病、腫瘤、糖尿病等）的細胞和分子機制，重點關注腸道粘膜免疫。
1.?Cao M#, Wu Z#, Lou Q#, Lu W, Zhang J, Li Q, Zhang Y, Yao Y, Zhao Q, Li M, Zhang H, Qian Y*. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cell Death Differ 2019 Dec;26(12):2622-2636
2.?Zhang Y#, Yao Y#, Qiu X, Wang G, Hu Z, Chen S, Wu Z, Yuan N, Gao H, Wang J, Song H, Girardin SE, Qian Y*. Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing. Nat Immunol 2019 Apr;20(4):433-446
3.?Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y*. Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles. Immunity 2019 Mar 19;50(3):692-706
4.?Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y*. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med 2018 Nov 5;215(11):2850-2867
5.?Shao X#, Chen S#, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep 2017 Aug 1;7(1):7024
6.?Xia M, Liu J, Liu S, Chen K, Lin H, Jiang M, Xu X, Xue Y, Liu W, Gu Y, Zhang X, Li Z, Yi L, Qian Y, Zhou C, Li R, Zhang X, Li Z, Cao X. Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity. Nat Commun 2017 Jun 9;8:15818
7.?Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X. IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. Nat Commun 2017 May 31;8:15508
8.?Yao Y, Chen S, Cao M, Fan X, Yang T, Huang H, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F*, Qian Y*. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun 2017 May 24;8:15402
9.?Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, Qian Y, Huang H, Wang X. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep 2017 Apr;18(4):586-602
10.?Song X, He X, Li X, Qian Y*. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 2016 Jul;13(4):418-431 (Invited review)
11.?Wang J, Song X, Qian Y*. Research advances in IL-17 cytokine family. Chinese Bulletin of Life Sciences 2016 Feb;28(2):170-181
12.?Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N*, Qian Y*. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity 2015 Sep 15;43(3):488–501
13.?Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H. MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. Nat Commun 2015 Jul 13;6:7639
14.?Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nat Commun 2015 May 12;6:7096
15.?Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ 2014 Nov;21(11):1758-1768
16.?Song X, Gao H, Qian Y*. Th17 Differentiation and Their Pro-inflammation Function. Adv Exp Med Biol 2014;841:99-151
(Xinyang Song, Hanchao Gao, Youcun Qian. Chaptor 5. T Helper Cell Differentiation and Their Function, Th17 Differentiation and Their Pro-inflammation Function, p99-152 in the book of Advances in Experimental Medicine and Biology, Volume 841, edited by Bing Sun)
17.?Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity 2014 Jan 16;40(1):140-152
(Featured by the journal; evaluated by Faculty of 1000; selected as best of Immunity 2014)
18.?Song X, Qian Y*. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal 2013 Jul 31;25(12):2335-2347 (Invited review)
19.?Song X, Qian Y*. Peli1 sets the CNS on fire. Nat Med 2013 May; 19(5):536-538 (Invited preview)
20.?Shu Z, Pan W, Qian Y*. MicroRNA in immunity and autoimmunity. J Mol Med (Berl) 2013 Sep;91(9):1039-1050 (Invited review)
21.?Song X, Qian Y*. The activation and regulation of IL-17 receptor mediated signaling. Cytokine 2013 May;62(2):175-182 (Invited review)
22.?Yao Y, Qian Y*. Expression regulation and function of NLRC5. Protein Cell 2013 Mar;4(3):168-175 (Invited review)
23.?Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y*. TRAF6 dependent Act1 phosphorylation by the IKK-related kinases suppresses IL-17-induced NF-κB activation. Mol Cell Biol 2012;32(19):3925-3937
24.?Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley J, Shen N*, Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 2012;18(7):1077-1086
(News and Views in Nat Med 2012;18:1009–1010; Research highlighted in Nat Rev Immunol 2012;doi:10.1038/nri3250; evaluated by F1000, 2012)
25.?Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y*. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 2012;22(5):836-847
(Research highlighted by Cell Res 2012;22(7):1099-1101; Research highlighted by A IBMN. Featured article in NPG immunology website)
26.?Zhu S, Qian Y*. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci 2012;122(11):487-511 (Invited review)
27.?Shi P, Zhu S, Liu YY, Liu YF, Liu Y, Chen Z, Shi Y, Qian Y*. Persistent Stimulation with Interleukin-17 Desensitizes Cells through SCFb-TrCP–Mediated Degradation of Act1. Sci Signal 2011;4(197):ra73
28.?Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y*. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 2011;12(12):1151-1158
(News and views in Nat Immunol; Research highlighted in Nat Rev Immunol; Previewed in Immunity; Featured article in NPG website; Evaluated twice as top 2% in Faculty of 1000 Biology and Medicine)
29.?Shi P, Zhu S, Qian Y*. Research on IL-17 mediated signaling and function. Chin. J Cell Biol 2011;33(4):345-357 (Invited review)
30.?Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y*. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 2010;207(12):2647-2662
(Research highlighted by Nat Med, Nat Immunol and SciBX; evaluated as top 2% in Faculty of 1000 Biology and Medicine)
31.?Qian Y*, Kang Z, Liu C, Li X*. IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol 2010;7(5):328-333 (Invited review)
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