最近中文字幕在线MV视频在线,最近2019年手机中文字幕,最近最新免费手机中文,最近最新MV在线观看免费高清,今天高清视频免费播放,最近免费MV在线观看动漫,最近中文字幕MV第一季歌词

姚依昆

姚依昆

博士
系統(tǒng)免疫學研究組組長

郵箱: ykyao@sinh.ac.cn

電話: +86-21-54920250

所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室

個人簡歷


  2023.04-至  今:中國科學院上海營養(yǎng)與健康研究所 研究員
  2017.04-2022.12:National Institutes of Health 博士后
  2013.08-2017.03:中國科學院上海生命科學研究院 博士后
  2008.09-2013.09:中國科學院上海生命科學研究院 博士
  

研究方向

免疫系統(tǒng)調控與炎癥性疾病

研究內容

  免疫系統(tǒng)功能的正常維持是保證機體健康的必要條件。本實驗室通過遺傳學、細胞生物學、分子生物學、微生物學和計算生物學等多學科技術手段來理解和擴展免疫系統(tǒng)如何參與疾病進程。通過遺傳修飾小鼠、疾病模型和臨床病人來闡析免疫系統(tǒng)的失調如何導致免疫缺陷、自身免疫、炎癥、過敏、慢性感染等重大疾病,重點關注黏膜免疫及抗腫瘤免疫。并基于前期分子機理研究,為腸道等慢性黏膜炎癥類疾病和腫瘤的免疫治療開發(fā)新型診斷與治療途徑。主要研究方向包括(1)腸道黏膜免疫的分子調控機制;(2)腫瘤細胞外基質與抗腫瘤免疫;(3)人類單基因遺傳病的致病機理。
  

代表論著(#第一作者,*通訊作者)

1. Gottlieb S, Shang W, Ye D, Kubo S, Jiang PD, Shafer S, Xu L, Zheng L, Park AY, Song J, Chan W, Zeng Z, He T, Schwarz B, H?upl B, Oellerich T, Lenardo MJ, Yao Y*. (2024) AMBRA1 controls the translation of immune-specific genes in T lymphocytes. Proc Natl Acad Sci U S A Oct 29;121(44):e2416722121

2. Yao Y, Shang W, Bao L, Peng Z, Wu C. (2024) Epithelial-immune cell crosstalk for intestinal barrier homeostasis. Eur J Immunol Jun;54(6):e2350631

3. Park AY, Leney-Greene M, Lynberg M, Gabrielski JQ, Xu X, Schwarz B, Zheng L, Balasubramaniyam A, Ham H, Chao B, Zhang Y, Matthews HF, Cui J, Yao Y, Kubo S, Chanchu JM, Morawski AR, Cook SA, Jiang P, Ravell JC, Cheng YH, George A, Faruqi A, Pagalilauan AM, Bergerson JRE, Ganesan S, Chauvin SD, Aluri J, Edwards-Hicks J, Bohrnsen E, Tippett C, Omar H, Xu L, Butcher GW, Pascall J, Karakoc-Aydiner E, Kiykim A, Maecker H, Tezcan ?, Esenboga S, Heredia RJ, Akata D, Tekin S, Kara A, Kuloglu Z, Unal E, Kendirli T, Dogu F, Karabiber E, Atkinson TP, Cochet C, Filhol O, Bosio CM, Davis MM, Lifton RP, Pearce EL, Daumke O, Aytekin C, ?ahin GE, Aksu Aü, Uzel G, Koneti Rao V, Sari S, Dalg?? B, Boztug K, Cagdas D, Haskologlu S, Ikinciogullari A, Schwefel D, Vilarinho S, Baris S, Ozen A, Su HC, Lenardo MJ. (2024) GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway. Nat Immunol Feb;25(2):282-293

4. Lixin Zheng*, Yikun Yao*, Michael J Lenardo*. (2023) Death receptor 5 rises to the occasion. Cell Res Mar;33(3):199-200

5. Yao Y#, Kim G#, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, Park AY, Jiang P, Li J, Baris S, Aydiner EK, Ertem D, Mulder DJ, Warner N, Griffiths AM, Topf-Olivestone C, Kori M, Werner L, Ouahed J, Field M, Liu C, Schwarz B, Bosio CM, Ganesan S, Song J, Urlaub H, Oellerich T, Malaker SA, Zheng L, Bertozzi CR, Zhang Y, Matthews H, Montgomery W, Shih HY, Jiang J, Jones M, Baras A, Shuldiner A, Gonzaga-Jauregui C, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan KT, Wu C*, Lenardo MJ*. (2022) Mucus sialylation determines intestinal host-commensal homeostasis. Cell Mar 31;185(7):1172-1188.e28

6. Yao Y#, Du Jiang P#, Chao BN#, Cagdas D#, Kubo S, Balasubramaniyam A, Zhang Y, Shadur B, NaserEddin A, Folio LR, Schwarz B, Bohrnsen E, Zheng L, Lynberg M, Gottlieb S, Leney-Greene MA, Park AY, Tezcan I, Akdogan A, Gocmen R, Onder S, Rosenberg A, Soilleux EJ, Johnson E, Jackson PK, Demeter J, Chauvin SD, Paul F, Selbach M, Bulut H, Clatworthy MR, Tuong ZK, Zhang H, Stewart BJ, Bosio CM, Stepensky P, Clare S, Ganesan S, Pascall JC, Daumke O, Butcher GW, McMichael AJ, Simon AK, Lenardo MJ*. (2022) GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. J Exp Med Jun 6;219(6):e20201405

7. Kubo S#, Kataria R, Yao Y, Gabrielski JQ, Zheng L, Markowitz TE, Chan W, Song J, Boddapati AK, Saeki K, Haupl B, Park AY, Cheng YH, Cui J, Oellerich T, Lenardo MJ*. (2022) Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. Proc Natl Acad Sci U S A Aug 16;119(33):e2208522119

8. Kubo S#, Fritz JM, Raquer-McKay HM, Kataria R, Vujkovic-Cvijin I, Al-Shaibi A, Yao Y, Zheng L, Zou J, Waldman AD, Jing X, Farley TK, Park AY, Oler AJ, Charles AK, Makhlouf M, AbouMoussa EH, Hasnah R, Saraiva LR, Ganesan S, Al-Subaiey AA, Matthews H, Flano E, Lee HH, Freeman AF, Sefer AP, Sayar E, Cakir E, Karakoc-Aydiner E, Baris S, Belkaid Y, Ozen A*, Lo B*, Lenardo MJ*. (2022) Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease. Nat Immunol 23(1):75-85

9. Gao H#, Cao M, Yao Y, Hu W, Sun H, Zhang Y, Zeng C, Tang J, Luan S, Chen P*. (2021) Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release. Front Immunol Oct 14;12:750841

10. Shafer S#, Yao Y#, Comrie W, Cook S, Zhang Y, Yesil G, Karakoc-Aydiner E, Baris S, Cokugras H, Aydemir S, Kiykim A, Ozen A, Lenardo M*. (2021) Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency. J Allergy Clin Immunol Jul;148(1):256-261.e2

11. Chan W#, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN*. (2021) Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools. Immunohorizons Feb 23;5(2):117-132

12. Zhang ZZ#, Zhang Y, He T, Sweeney CL, Baris S, Karakoc-Aydiner E, Yao Y, Ertem D, Matthews HF, Gonzaga-Jauregui C, Malech HL, Su HC, Ozen A, Smith KGC, Lenardo MJ*. (2021) Homozygous IL37 mutation associated with infantile inflammatory bowel disease. Proc Natl Acad Sci U S A Mar 9;118(10):e2009217118

13. Cao M#, Wu Z#, Lou Q#, Lu W, Zhang J, Li Q, Zhang Y, Yao Y, Zhao Q, Li M, Zhang H, Qian Y*. (2019) Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cell Death Differ Dec;26(12):2622-2636

14. Zhang Y#, Yao Y#, Qiu X, Wang G, Hu Z, Chen S, Wu Z, Yuan N, Gao H, Wang J, Song H, Girardin SE, Qian Y*. (2019) Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing. Nat Immunol Apr;20(4):433-446

15. Chen S#, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y*. (2018) USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med Nov 5;215(11):2850-2867

16. Wang Z#, Yin W, Zhu L, Li J, Yao Y, Chen F, Sun M, Zhang J, Shen N, Song Y, Chang X*. (2018) Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production. Immunity Jul 17;49(1):80-92.e7

17. Huang Y#, Liu K, Li Q, Yao Y, Wang Y*. (2018) Exosomes Function in Tumor Immune Microenvironment. Adv Exp Med Biol 1056:109-122

18. Wang S#, Tang L, Lin J, Shen Z, Yao Y, Wang W, Tao S, Gu C, Ma J, Xie Y, Liu Y*. (2017) ABCB5 promotes melanoma metastasis through enhancing NF-kappaB p65 protein stability. Biochem Biophys Res Commun Oct 7;492(1):18-26

19. Shao X#, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X, Qian Y*. (2017) FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep Aug 1;7(1):7024

20. Yao Y#, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y*. (2017) Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun May 24;8:15402

21. Song X#, Dai D#, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N*, Qian Y*. (2015) Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity Sep 15;43(3):488-501

22. Song X#, Gao H#, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. (2014) Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity Jan 16;40(1):140-152

23. Yao Y#, Qian Y*. (2013) Expression regulation and function of NLRC5. Protein Cell Mar;4(3):168-175

24. Yao Y#, Wang Y#, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y*. (2012) NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res May;22(5):836-847

婷婷五月丁香久久| 久久人妻久久久久| 天天做天天爱| 啪啪啪啪五月天| 色哟哟精品| 天天久久婷婷| 丁香五月自拍| 久99热在线观看| 色婷婷五月丁香色| 天天日天天草| 26uuuavcom| 99在线精品视频观看免费下载| 激情九月综合| 色九月婷婷| 久久久99婷婷久久久久久| 狠狠色噜噜狠狠狠狠狠色综合久久| 五月婷婷丁香瑟瑟视频| 伊人五月久久| 丁香六月婷婷激情综合| 日韩精品一品二区三区的使用体验| 久久这里只有精品视频15 | 日韩xx在线| 久久9热好| 色狠久| 操逼在线视频| 九九视频这里只有精品在线播放 | 丁香五月婷婷啪啪视频| 丁香婷婷中文字幕| 婷婷成人综合免费视频| 丁香五月亚洲AV| 激情另类综合| 亚洲精品乱码久久久久久按摩观| 激情五月伊人婷婷| 思思久久99热| 激情综合五月| 亚洲精品操一操、噜一噜、摸一摸、爽 | 深爱激情五月网| 九九热视频精品| 嫩草极品| 久热爱大香蕉在线蜜臀悦色 | 婷婷五月丁综合|