郵箱: ykyao@sinh.ac.cn
電話: +86-21-54920250
所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室
2023.04-至 今：中國科學院上海營養(yǎng)與健康研究所 研究員
2017.04-2022.12：National Institutes of Health 博士后
2013.08-2017.03：中國科學院上海生命科學研究院 博士后
2008.09-2013.09：中國科學院上海生命科學研究院 博士
免疫系統(tǒng)調控與炎癥性疾病
免疫系統(tǒng)功能的正常維持是保證機體健康的必要條件。本實驗室通過遺傳學、細胞生物學、分子生物學、微生物學和計算生物學等多學科技術手段來理解和擴展免疫系統(tǒng)如何參與疾病進程。通過遺傳修飾小鼠、疾病模型和臨床病人來闡析免疫系統(tǒng)的失調如何導致免疫缺陷、自身免疫、炎癥、過敏、慢性感染等重大疾病，重點關注黏膜免疫及抗腫瘤免疫。并基于前期分子機理研究，為腸道等慢性黏膜炎癥類疾病和腫瘤的免疫治療開發(fā)新型診斷與治療途徑。主要研究方向包括（1）腸道黏膜免疫的分子調控機制；（2）腫瘤細胞外基質與抗腫瘤免疫；（3）人類單基因遺傳病的致病機理。
1. Gottlieb S, Shang W, Ye D, Kubo S, Jiang PD, Shafer S, Xu L, Zheng L, Park AY, Song J, Chan W, Zeng Z, He T, Schwarz B, H?upl B, Oellerich T, Lenardo MJ, Yao Y*. (2024) AMBRA1 controls the translation of immune-specific genes in T lymphocytes. Proc Natl Acad Sci U S A Oct 29;121(44):e2416722121
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4. Lixin Zheng*, Yikun Yao*, Michael J Lenardo*. (2023) Death receptor 5 rises to the occasion. Cell Res Mar;33(3):199-200
5. Yao Y#, Kim G#, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, Park AY, Jiang P, Li J, Baris S, Aydiner EK, Ertem D, Mulder DJ, Warner N, Griffiths AM, Topf-Olivestone C, Kori M, Werner L, Ouahed J, Field M, Liu C, Schwarz B, Bosio CM, Ganesan S, Song J, Urlaub H, Oellerich T, Malaker SA, Zheng L, Bertozzi CR, Zhang Y, Matthews H, Montgomery W, Shih HY, Jiang J, Jones M, Baras A, Shuldiner A, Gonzaga-Jauregui C, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan KT, Wu C*, Lenardo MJ*. (2022) Mucus sialylation determines intestinal host-commensal homeostasis. Cell Mar 31;185(7):1172-1188.e28
6. Yao Y#, Du Jiang P#, Chao BN#, Cagdas D#, Kubo S, Balasubramaniyam A, Zhang Y, Shadur B, NaserEddin A, Folio LR, Schwarz B, Bohrnsen E, Zheng L, Lynberg M, Gottlieb S, Leney-Greene MA, Park AY, Tezcan I, Akdogan A, Gocmen R, Onder S, Rosenberg A, Soilleux EJ, Johnson E, Jackson PK, Demeter J, Chauvin SD, Paul F, Selbach M, Bulut H, Clatworthy MR, Tuong ZK, Zhang H, Stewart BJ, Bosio CM, Stepensky P, Clare S, Ganesan S, Pascall JC, Daumke O, Butcher GW, McMichael AJ, Simon AK, Lenardo MJ*. (2022) GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. J Exp Med Jun 6;219(6):e20201405
7. Kubo S#, Kataria R, Yao Y, Gabrielski JQ, Zheng L, Markowitz TE, Chan W, Song J, Boddapati AK, Saeki K, Haupl B, Park AY, Cheng YH, Cui J, Oellerich T, Lenardo MJ*. (2022) Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. Proc Natl Acad Sci U S A Aug 16;119(33):e2208522119
8. Kubo S#, Fritz JM, Raquer-McKay HM, Kataria R, Vujkovic-Cvijin I, Al-Shaibi A, Yao Y, Zheng L, Zou J, Waldman AD, Jing X, Farley TK, Park AY, Oler AJ, Charles AK, Makhlouf M, AbouMoussa EH, Hasnah R, Saraiva LR, Ganesan S, Al-Subaiey AA, Matthews H, Flano E, Lee HH, Freeman AF, Sefer AP, Sayar E, Cakir E, Karakoc-Aydiner E, Baris S, Belkaid Y, Ozen A*, Lo B*, Lenardo MJ*. (2022) Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease. Nat Immunol 23(1):75-85
9. Gao H#, Cao M, Yao Y, Hu W, Sun H, Zhang Y, Zeng C, Tang J, Luan S, Chen P*. (2021) Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release. Front Immunol Oct 14;12:750841
10. Shafer S#, Yao Y#, Comrie W, Cook S, Zhang Y, Yesil G, Karakoc-Aydiner E, Baris S, Cokugras H, Aydemir S, Kiykim A, Ozen A, Lenardo M*. (2021) Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency. J Allergy Clin Immunol Jul;148(1):256-261.e2
11. Chan W#, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN*. (2021) Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools. Immunohorizons Feb 23;5(2):117-132
12. Zhang ZZ#, Zhang Y, He T, Sweeney CL, Baris S, Karakoc-Aydiner E, Yao Y, Ertem D, Matthews HF, Gonzaga-Jauregui C, Malech HL, Su HC, Ozen A, Smith KGC, Lenardo MJ*. (2021) Homozygous IL37 mutation associated with infantile inflammatory bowel disease. Proc Natl Acad Sci U S A Mar 9;118(10):e2009217118
13. Cao M#, Wu Z#, Lou Q#, Lu W, Zhang J, Li Q, Zhang Y, Yao Y, Zhao Q, Li M, Zhang H, Qian Y*. (2019) Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cell Death Differ Dec;26(12):2622-2636
14. Zhang Y#, Yao Y#, Qiu X, Wang G, Hu Z, Chen S, Wu Z, Yuan N, Gao H, Wang J, Song H, Girardin SE, Qian Y*. (2019) Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing. Nat Immunol Apr;20(4):433-446
15. Chen S#, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y*. (2018) USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med Nov 5;215(11):2850-2867
16. Wang Z#, Yin W, Zhu L, Li J, Yao Y, Chen F, Sun M, Zhang J, Shen N, Song Y, Chang X*. (2018) Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production. Immunity Jul 17;49(1):80-92.e7
17. Huang Y#, Liu K, Li Q, Yao Y, Wang Y*. (2018) Exosomes Function in Tumor Immune Microenvironment. Adv Exp Med Biol 1056:109-122
18. Wang S#, Tang L, Lin J, Shen Z, Yao Y, Wang W, Tao S, Gu C, Ma J, Xie Y, Liu Y*. (2017) ABCB5 promotes melanoma metastasis through enhancing NF-kappaB p65 protein stability. Biochem Biophys Res Commun Oct 7;492(1):18-26
19. Shao X#, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X, Qian Y*. (2017) FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep Aug 1;7(1):7024
20. Yao Y#, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y*. (2017) Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun May 24;8:15402
21. Song X#, Dai D#, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N*, Qian Y*. (2015) Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity Sep 15;43(3):488-501
22. Song X#, Gao H#, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y*. (2014) Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity Jan 16;40(1):140-152
23. Yao Y#, Qian Y*. (2013) Expression regulation and function of NLRC5. Protein Cell Mar;4(3):168-175
24. Yao Y#, Wang Y#, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y*. (2012) NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res May;22(5):836-847
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